Grant support: DoD W81XWH-18-1-0774
PI: Drs. Ivan Rosas and Dr. George Washko
Molecular Profiles of Smokers with Subclinical Interstitial Lung Disease
The goals of this projects are: 1) Determine prevalence and long-term progression of subclinical ILD in smokers enrolled in PLuSS. We hypothesize that interstitial abnormalities in a fibrotic subpleural distribution will be progressive while those with a centrilobular non-fibrotic distribution will remain stable or improve. We will iteratively refine our computer-based algorithms for image interpretation and perform an objective CT examination to assess progression, stability or regression of these changes and examine their clinical correlates in the PLuSS Cohort. 2) Define clinical and molecular determinants that predict progression of subclinical ILD in smokers. We hypothesize that clinical and molecular determinants that portend a poor prognosis in IPF patients can predict progression of subclinical ILD. 3) Identify clinical and molecular determinants that predict the development of subclinical ILD in smokers. We hypothesize those clinical and molecular determinants that predict disease progression in IPF patients can also predict the development of subclinical ILD in smokers.
