Grant support: NIH/NHLBI 1R01HL107246

PI: Dr. George R. Washko

Project Information:

The goal of this project is to provide detailed objective measures of emphysema, airway disease, and vascular disease in a subset of subjects enrolled in the STATCOPE Investigation (a randomized trial of simvastatin or placebo for the prevention of AECOPD).  CT scans will be performed at baseline and study termination.  We may then be able to determine which subjects best respond to such therapeutic intervention and if statin therapy mitigates disease-related progression in CT measures of emphysema, airway, and vascular disease.

People Involved:

Dr. Samuel Yoffe Ash, Dr. Carolyn E. Come, Christopher Dale, Dr. Alejandro A. Diaz, Dr. Rola Harmouche, Dr. Farbod Nicholas Rahaghi, Dr. George R Washko

Publications:

Washko GR, Parraga G, Coxson HO. Quantitative pulmonary imaging using computed tomography and magnetic resonance imaging. Respirology 2012;17(3):432-44. Abstract

Xu J-F, Washko GR, Nakahira K, Hatabu H, Patel AS, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, San José Estépar R, Diaz AA, Li H-P, Qu J-M, Himes BE, Come CE, D’Aco K, Martinez FJ, Han MLK, Lynch DA, Crapo JD, Morse D, Ryter SW, Silverman EK, Rosas IO, Choi AMK, Hunninghake GM. Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med 2012;185(5):547-56. Abstract

 Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome

Gazourian L, Rogers AJ, Ibanga R, Weinhouse GL, Pinto-Plata V, Ritz J, Soiffer RJ, Antin JH, Washko GR, Baron RM, Ho VT. Factors associated with bronchiolitis obliterans syndrome and chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation. Am J Hematol 2014;89(4):404-9. Abstract

Hunninghake GM, Hatabu H, Okajima Y, Gao W, Dupuis J, Latourelle JC, Nishino M, Araki T, Zazueta OE, Kurugol S, Ross JC, San José Estépar R, Murphy E, Steele MP, Loyd JE, Schwarz MI, Fingerlin TE, Rosas IO, Washko GR, O’Connor GT, Schwartz DA. MUC5B promoter polymorphism and interstitial lung abnormalities. N Engl J Med 2013;368(23):2192-200. Abstract

 n._engl._j._med._2013_hunninghake.pdf

Castaldi PJ, San José Estépar R, Mendoza CS, Hersh CP, Laird N, Crapo JD, Lynch DA, Silverman EK, Washko GR. Distinct quantitative computed tomography emphysema patterns are associated with physiology and function in smokers. Am J Respir Crit Care Med 2013;188(9):1083-90. Abstract

Castaldi PJ, Cho MH, San José Estépar R, McDonald M-LN, Laird N, Beaty TH, Washko G, Crapo JD, Silverman EK. Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. Am J Respir Crit Care Med 2014;190(4):399-409. Abstract