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Association between acute respiratory disease events and the promoter polymorphism in smokers

Citation:

Ash SY, Harmouche R, Putman RK, Ross JC, Martinez FJ, Choi AM, Bowler RP, Regan EA, Curtis JL, Han MLK, Boucher RC, O'Neal WK, Hatabu H, Lynch DA, Rosas IO, Hunninghake GM, San José Estépar R, Washko GR, Washko GR. Association between acute respiratory disease events and the promoter polymorphism in smokers. Thorax 2018;73(11):1071-1074.

Date Published:

2018 11

Abstract:

A single-nucleotide polymorphism (rs35705950) in the mucin 5B () gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects. In non-Hispanic whites in the COPDGene cohort with interstitial features (n=454), the promoter polymorphism was associated with a 61% lower odds of a prospectively reported acute respiratory disease event (P=0.001), a longer time-to-first event (HR=0.57; P=0.006) and 40% fewer events (P=0.016). The promoter polymorphism may have a beneficial effect on the risk of acute respiratory disease events in smokers with interstitial CT features.

Last updated on 04/30/2019