@article {1675041,
	title = {Traction Bronchiectasis/Bronchiolectasis is Associated with Interstitial Lung Abnormality Mortality},
	journal = {Eur J Radiol},
	volume = {129},
	year = {2020},
	month = {2020 Aug},
	pages = {109073},
	abstract = {PURPOSE: To investigate if the presence and severity of traction bronchiectasis/bronchiolectasis are associated with poorer survival in subjects with ILA.

METHOD: The study included 3,594 subjects (378 subjects with ILA and 3,216 subjects without ILA) in AGES-Reykjavik Study. Chest CT scans of 378 subjects with ILA were evaluated for traction bronchiectasis/bronchiolectasis, defined as dilatation of bronchi/bronchioles within areas demonstrating ILA. Traction bronchiectasis/bronchiolectasis Index (TBI) was assigned as: TBI = 0, ILA without traction bronchiectasis/bronchiolectasis: TBI = 1, ILA with bronchiolectasis but without bronchiectasis or architectural distortion: TBI = 2, ILA with mild to moderate traction bronchiectasis: TBI = 3, ILA and severe traction bronchiectasis and/or honeycombing. Overall survival (OS) was compared among the subjects in different TBI groups and those without ILA.

RESULTS: The median OS was 12.93 years (95\%CI; 12.67 - 13.43) in the subjects without ILA; 11.95 years (10.03 - not reached) in TBI-0 group; 8.52 years (7.57 - 9.30) in TBI-1 group; 7.63 years (6.09 - 9.10) in TBI-2 group; 5.40 years (1.85 - 5.98) in TBI-3 group. The multivariable Cox models demonstrated significantly shorter OS of TBI-1, TBI-2, and TBI-3 groups compared to subjects without ILA (P \< 0.0001), whereas TBI-0 group had no significant OS difference compared to subjects without ILA, after adjusting for age, sex, and smoking status.

CONCLUSIONS: The presence and severity of traction bronchiectasis/bronchiolectasis are associated with shorter survival. The traction bronchiectasis/bronchiolectasis is an important contributor to increased mortality among subjects with ILA.},
	keywords = {Aged, Aged, 80 and over, Bronchiectasis, Cohort Studies, Female, Humans, Iceland, Longitudinal Studies, Lung, Lung Diseases, Interstitial, Male, Proportional Hazards Models, Severity of Illness Index, Survival Analysis, Tomography, X-Ray Computed},
	issn = {1872-7727},
	doi = {10.1016/j.ejrad.2020.109073},
	author = {Hida, Tomoyuki and Nishino, Mizuki and Hino, Takuya and Lu, Junwei and Putman, Rachel K and Gudmundsson, Elias F and Araki, Tetsuro and Valtchinov, Vladimir I and Honda, Osamu and Yanagawa, Masahiro and Yamada, Yoshitake and Hata, Akinori and Jinzaki, Masahiro and Tomiyama, Noriyuki and Honda, Hiroshi and Estepar, Raul San Jose and Washko, George R and Johkoh, Takeshi and Christiani, David C and Lynch, David A and Gudnason, Vilmundur and Gudmundsson, Gunnar and Hunninghake, Gary M and Hatabu, Hiroto}
}