@article {1433731,
	title = {Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease},
	journal = {Thorax},
	volume = {67},
	number = {5},
	year = {2012},
	month = {2012 May},
	pages = {399-406},
	abstract = {BACKGROUND: The value of quantitative CT (QCT) to identify chronic obstructive pulmonary disease (COPD) phenotypes is increasingly appreciated. The authors hypothesised that QCT-defined emphysema and airway abnormalities relate to St George{\textquoteright}s Respiratory Questionnaire (SGRQ) and Body-Mass Index, Airflow Obstruction, Dyspnea and Exercise Capacity Index (BODE).

METHODS: 1200 COPDGene subjects meeting Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria for COPD with QCT analysis were included. Total lung emphysema was measured using the density mask technique with a -950 Hounsfield unit threshold. An automated programme measured mean wall thickness (WT), wall area percentage (WA\%) and 10 mm lumenal perimeter (pi10) in six segmental bronchi. Separate multivariate analyses examined the relative influence of airway measures and emphysema on SGRQ and BODE.

RESULTS: In separate models predicting SGRQ score, a 1 unit SD increase in each airway measure predicted higher SGRQ scores (for WT, 1.90 points higher, p=0.002; for WA\%, 1.52 points higher, p=0.02; for pi10, 2.83 points higher p,
	keywords = {Aged, Aged, 80 and over, Body Mass Index, Dyspnea, Emphysema, Female, Health Status, Humans, Lung, Male, Middle Aged, Multivariate Analysis, Pulmonary Disease, Chronic Obstructive, Regression Analysis, Spirometry, Surveys and Questionnaires, Tomography, X-Ray Computed},
	issn = {1468-3296},
	doi = {10.1136/thoraxjnl-2011-201185},
	author = {Martinez, Carlos H and Chen, Ya-Hong and Westgate, Phillip M and Liu, Lyrica X and Murray, Susan and Curtis, Jeffrey L and Make, Barry J and Kazerooni, Ella A and Lynch, David A and Marchetti, Nathaniel and Washko, George R and Martinez, Fernando J and Han, MeiLan K}
}