@article {1433717, title = {Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD}, journal = {Respir Res}, volume = {14}, year = {2013}, month = {2013 Apr 08}, pages = {42}, abstract = {BACKGROUND: Gas trapping quantified on chest CT scans has been proposed as a surrogate for small airway disease in COPD. We sought to determine if measurements using paired inspiratory and expiratory CT scans may be better able to separate gas trapping due to emphysema from gas trapping due to small airway disease. METHODS: Smokers with and without COPD from the COPDGene Study underwent inspiratory and expiratory chest CT scans. Emphysema was quantified by the percent of lung with attenuation , keywords = {Comorbidity, Female, Humans, Male, Middle Aged, Prevalence, Pulmonary Alveoli, Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema, Radiographic Image Enhancement, Radiography, Thoracic, Reproducibility of Results, Respiratory Mechanics, Sensitivity and Specificity, Smoking, Tomography, X-Ray Computed, United States}, issn = {1465-993X}, doi = {10.1186/1465-9921-14-42}, author = {Hersh, Craig P and Washko, George R and San Jos{\'e} Est{\'e}par, Ra{\'u}l and Lutz, Sharon and Friedman, Paul J and Han, MeiLan K and Hokanson, John E and Judy, Philip F and Lynch, David A and Make, Barry J and Marchetti, Nathaniel and Newell, John D and Sciurba, Frank C and Crapo, James D and Silverman, Edwin K} }