@article {1433617,
	title = {Lung Mass in Smokers},
	journal = {Acad Radiol},
	volume = {24},
	number = {4},
	year = {2017},
	month = {2017 04},
	pages = {386-392},
	abstract = {RATIONALE AND OBJECTIVE: Emphysema is characterized by airspace dilation, inflammation, and irregular deposition of elastin and collagen in the interstitium. Computed tomographic studies have reported that lung mass (LM) may be increased in smokers, a finding attributed to inflammatory and parenchymal remodeling processes observed on histopathology. We sought to examine the epidemiologic and clinical associations of LM in smokers.

MATERIALS AND METHODS: Baseline epidemiologic, clinical, and computed tomography (CT) data (n = 8156) from smokers enrolled into the COPDGene Study were analyzed. LM was calculated from the CT scan. Changes in lung function at 5 years{\textquoteright} follow-up were available from 1623 subjects. Regression analysis was performed to assess for associations of LM with forced expiratory volume in 1 second (FEV) and FEV decline.

RESULTS: Subjects with Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1 chronic obstructive pulmonary disease had greater LM than either smokers with normal lung function or those with GOLD 2-4 chronic obstructive pulmonary disease (P ,
	keywords = {Aged, Airway Remodeling, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Lung, Male, Middle Aged, Organ Size, Pulmonary Emphysema, Regression Analysis, Respiratory Function Tests, Smokers, Smoking, Tomography, X-Ray Computed, United States},
	issn = {1878-4046},
	doi = {10.1016/j.acra.2016.10.011},
	author = {Washko, George R and Kinney, Gregory L and Ross, James C and San Jos{\'e} Est{\'e}par, Ra{\'u}l and Han, MeiLan K and Dransfield, Mark T and Kim, Victor and Hatabu, Hiroto and Come, Carolyn E and Bowler, Russell P and Silverman, Edwin K and Crapo, James and Lynch, David A and Hokanson, John and Diaz, Alejandro A}
}