@article {1433552,
	title = {Cigarette Smoke Exposure and Radiographic Pulmonary Vascular Morphology in the Framingham Heart Study},
	journal = {Ann Am Thorac Soc},
	volume = {16},
	number = {6},
	year = {2019},
	month = {2019 Jun},
	pages = {698-706},
	abstract = {Rationale: Cigarette smoke exposure is a risk factor for many lung diseases, and histologic studies suggest that tobacco-related vasoconstriction and vessel loss plays a role in the development of emphysema. However, it remains unclear how tobacco affects the pulmonary vasculature in general populations with a typical range of tobacco exposure, and whether these changes are detectable by radiographic methods. Objectives: To determine whether tobacco exposure in a generally healthy population manifests as lower pulmonary blood vessel volumes and vascular pruning on imaging. Methods: A total of 2,410 Framingham Heart Study participants with demographic data and smoking history underwent volumetric whole-lung computed tomography from 2008 to 2011. Automated algorithms calculated the total blood volume of all intrapulmonary vessels (TBV), smaller peripheral vessels (defined as cross-sectional area \<5 mm2 [BV5]), and the relative fraction of small vessels (BV5/TBV). Tobacco exposure was assessed as smoking status, cumulative pack-years, and second-hand exposure. We constructed multivariable linear regression models to evaluate associations of cigarette exposure and pulmonary blood vessel volume measures, adjusting for demographic covariates, including age, sex, height, weight, education, occupation, and median neighborhood income. Results: All metrics of tobacco exposure (including smoking status, pack-years, and second-hand exposure) were consistently associated with higher absolute pulmonary blood vessel volume, higher small vessel volume, and/or higher small vessel fraction. For example, ever-smokers had a 4.6 ml higher TBV (95\% confidence interval [CI] = 2.9-6.3, P \< 0.001), 2.1 ml higher BV5 (95\% CI = 1.3-2.9, P \< 0.001), and 0.28 percentage-point-higher BV5/TBV (95\% CI = 0.03-0.52, P = 0.03) compared with never-smokers. These associations remained significant after adjustment for percent predicted forced expiratory volume in 1 second, cardiovascular comorbidities, and did not differ based on presence or absence of airflow obstruction. Conclusions: Using computed tomographic imaging, we found that cigarette exposure was associated with higher pulmonary blood vessel volumes, especially in the smaller peripheral vessels. Although, histologically, tobacco-related vasculopathy is characterized by vessel narrowing and loss, our results suggest that radiographic vascular pruning may not be a surrogate of these pathologic changes.},
	keywords = {Aged, Cigarette Smoking, Ex-Smokers, Female, Forced Expiratory Volume, Humans, Linear Models, Longitudinal Studies, Lung, Male, Middle Aged, Multidetector Computed Tomography, Multivariate Analysis, Non-Smokers, Organ Size, Pulmonary Artery, Pulmonary Emphysema, Pulmonary Veins, Smokers, Spirometry, Tobacco Smoke Pollution, Vital Capacity},
	issn = {2325-6621},
	doi = {10.1513/AnnalsATS.201811-795OC},
	author = {Synn, Andrew J and Zhang, Chunyi and Washko, George R and San Jos{\'e} Est{\'e}par, Ra{\'u}l and O{\textquoteright}Connor, George T and Li, Wenyuan and Mittleman, Murray A and Rice, Mary B}
}