@article {1433718,
	title = {CT and physiologic determinants of dyspnea and exercise capacity during the six-minute walk test in mild COPD},
	journal = {Respir Med},
	volume = {107},
	number = {4},
	year = {2013},
	month = {2013 Apr},
	pages = {570-9},
	abstract = {OBJECTIVES: We aimed to explore physiological responses to the six-minute walk test (6MWT) and assess computed tomographic (CT) features of the lungs and thigh muscle in order to determine contributors to dyspnea intensity and exercise limitation in dyspneic and non-dyspneic subjects with GOLD-1 COPD and controls.

METHODS: We compared Borg dyspnea ratings, ventilatory responses to 6MWT, and CT-measures of emphysema, airway lumen caliber, and cross-sectional area of the thigh muscle (RTMCT-CSA) in 19 dyspneic, 22 non-dyspneic, and 30 control subjects.

RESULTS: Dyspneic subjects walked less and experienced greater exertional breathlessness than non-dyspneic (105~m less and 2.4 Borg points more, respectively) and control subjects (94~m less and 2.6 Borg points more, respectively (P~,
	keywords = {Aged, Cross-Sectional Studies, Dyspnea, Exercise Test, Exercise Tolerance, Female, Humans, Lung, Male, Middle Aged, Muscle, Skeletal, Oxygen Consumption, Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema, Respiratory Mechanics, Thigh, Tomography, X-Ray Computed, Walking},
	issn = {1532-3064},
	doi = {10.1016/j.rmed.2012.12.011},
	author = {D{\'\i}az, Alejandro A and Morales, Arturo and D{\'\i}az, Juan C and Ramos, Crist{\'o}bal and Klaassen, Julieta and Sald{\'\i}as, Fernando and Aravena, Carlos and D{\'\i}az, Rodrigo and Lisboa, Carmen and Washko, George R and D{\'\i}az, Orlando}
}