@article {1433682,
	title = {An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease},
	journal = {Am J Respir Crit Care Med},
	volume = {191},
	number = {7},
	year = {2015},
	month = {2015 Apr 01},
	pages = {e4-e27},
	abstract = {BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and resource use worldwide. The goal of this Official American Thoracic Society (ATS)/European Respiratory Society (ERS) Research Statement is to describe evidence related to diagnosis, assessment, and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management.

METHODS: Clinicians, researchers, and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarized, and then salient knowledge gaps were identified.

RESULTS: Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus.

CONCLUSIONS: Great strides have been made in the diagnosis, assessment, and management of COPD as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ERS Research Statement highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centered outcomes.},
	keywords = {Biomedical Research, Europe, Evidence-Based Medicine, Humans, Organizational Objectives, Policy Making, Pulmonary Disease, Chronic Obstructive, Societies, Medical, United States},
	issn = {1535-4970},
	doi = {10.1164/rccm.201501-0044ST},
	author = {Celli, Bartolome R and Decramer, Marc and Wedzicha, Jadwiga A and Wilson, Kevin C and Agust{\'\i}, Alvar and Criner, Gerard J and MacNee, William and Make, Barry J and Rennard, Stephen I and Stockley, Robert A and Vogelmeier, Claus and Anzueto, Antonio and Au, David H and Barnes, Peter J and Burgel, Pierre-Regis and Calverley, Peter M and Casanova, Ciro and Clini, Enrico M and Cooper, Christopher B and Coxson, Harvey O and Dusser, Daniel J and Fabbri, Leonardo M and Fahy, Bonnie and Ferguson, Gary T and Fisher, Andrew and Fletcher, Monica J and Hayot, Maurice and Hurst, John R and Jones, Paul W and Mahler, Donald A and Maltais, Fran{\c c}ois and Mannino, David M and Martinez, Fernando J and Miravitlles, Marc and Meek, Paula M and Papi, Alberto and Rabe, Klaus F and Roche, Nicolas and Sciurba, Frank C and Sethi, Sanjay and Siafakas, Nikos and Sin, Don D and Soriano, Joan B and Stoller, James K and Tashkin, Donald P and Troosters, Thierry and Verleden, Geert M and Verschakelen, Johny and Vestbo, Jorgen and Walsh, John W and Washko, George R and Wise, Robert A and Wouters, Emiel F M and ZuWallack, Richard L}
}