@article {1433722,
	title = {Airway dilation in bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation},
	journal = {Respir Med},
	volume = {107},
	number = {2},
	year = {2013},
	month = {2013 Feb},
	pages = {276-83},
	abstract = {RATIONALE: Bronchiolitis obliterans syndrome (BOS) is a late, non-infectious pulmonary complication following hematopoietic stem cell transplantation (HSCT). There is minimal data published on quantitative radiologic characterization of airway remodeling in these subjects.

OBJECTIVES: To examine quantitative measurements of airway morphology and their correlation with lung function in a cohort of patients who underwent HSCT and developed BOS.

METHODS: All adult patients who underwent allogeneic HSCT at the Dana-Farber Cancer Institute/Brigham and Women{\textquoteright}s Hospital (n~=~1854) between January 1st 2000 and June 30th 2010 were screened for the development of BOS. Clinically acquired high resolution CT (HRCT) scans of the chest were collected. For each subjects discrete measures of airway wall area were performed and the square root of wall area of a 10-mm luminal perimeter (Pi10) was calculated.

MEASUREMENTS AND MAIN RESULTS: We identified 88 cases of BOS, and 37 of these patients had available HRCT. On CT scans obtained after BOS diagnosis, the Pi10 decreased (consistent with airway dilation) as compared with pre-BOS values (p~,
	keywords = {Adult, Aged, Airway Remodeling, Bronchi, Bronchiolitis Obliterans, Bronchography, Case-Control Studies, Dilatation, Pathologic, Female, Forced Expiratory Volume, Hematopoietic Stem Cell Transplantation, Humans, Male, Middle Aged, Tomography, X-Ray Computed, Vital Capacity, Young Adult},
	issn = {1532-3064},
	doi = {10.1016/j.rmed.2012.11.002},
	author = {Gazourian, Lee and Coronata, Anna Maria F and Rogers, Angela J and Weinhouse, Gerald L and Soiffer, Robert J and Antin, Joseph H and Ritz, Jerome and Ho, Vincent T and Baron, Rebecca M and Washko, George R}
}