@article {472986,
	title = {Abdominal Visceral Adipose Tissue is Associated with Myocardial Infarction in Patients with COPD.},
	journal = {Chronic obstructive pulmonary diseases (Miami, Fla.)Chronic obstructive pulmonary diseases (Miami, Fla.)},
	volume = {2},
	year = {2015},
	pages = {8-16},
	abstract = {BACKGROUND:Cardiovascular diseases are frequent and a major cause of death in patients with chronic obstructive pulmonary disease (COPD). In the general population, various fat depots including abdominal visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and liver fat have been linked to increased risk of cardiovascular diseases. We hypothesize that these adipose tissue compartments are associated with myocardial infarction (MI) in patients with COPD.METHODS:We collected measures of VAT and SAT areas and liver attenuation on the computed tomography scan of the chest from 1267 patients with COPD. MI was a self-reported physician-diagnosed outcome. The association between fat depots and self-reported history of MI was assessed by logistic regression analysis in which the patients within the 2 lowest tertiles of VAT and SAT areas were the reference group.RESULTS:Eighty three patients (6.6\%) reported a history of MI at the time of enrollment. Compared to patients who did not have an MI episode, those who had a prior MI had a higher VAT area (mean {\textpm} SD, 303.4 {\textpm} 208.5 vs. 226.8 {\textpm} 172.6 cm(2); P=0.002) with no differences in SAT area and liver fat. After adjustment for age, gender, obesity, pack years of smoking, hypertension, high cholesterol, and diabetes, patients within the upper tertile (vs. those in the lower tertiles) of VAT area had increased odds of MI (odds ratio [OR] 1.86, 95\% confidence interval [CI] 1.02 - 3.41).CONCLUSION:Increased abdominal visceral fat is independently associated with a history of MI in individuals with COPD.},
	author = {Diaz, Alejandro A and Young, Tom P and Kurugol, Sila and Eckbo, Erick and Muralidhar, Nina and Chapman, Joshua K and Kinney, Gregory L and Ross, James C and San Jose Est{\'e}par, Ra{\'u}l and Harmouche, Rola and Black-Shinn, Jennifer L and Budoff, Matthew and Bowler, Russell P and Hokanson, John and Washko, George R and COPDGene investigators}
}