@article {473451, title = {2006 International Conference of the IEEE Engineering in Medicine and Biology Society}, journal = {Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. ConferenceConference proceedings : ... Annual International Conference of the IEEE Engi}, volume = {Suppl}, year = {2006}, month = {Aug 30}, pages = {6707-6710}, address = {New York City}, abstract = {In this paper we propose a formal formulation for the estimation of Diffusion Tensors in the space of symmetric positive semidefinite (PSD) tensors. Traditionally, diffusion tensor model estimation has been carried out imposing tensor symmetry without constraints for negative eigenvalues. When diffusion weighted data does not follow the diffusion model,due to noise or signal drop, negative eigenvalues may arise. An estimation method that accounts for the positive definiteness is desirable to respect the underlying principle of diffusion. This paper proposes such an estimation method and provides a theoretical interpretation of the result. A closed-form solution is derived that is the optimal data-fit in the matrix 2-norm sense,removing the need for optimization-based tensor estimation.}, author = {Niethammer, Marc and San Jose Est{\'e}par, Ra{\'u}l and Bouix, Sylvain and Shenton, Martha and Westin, Carl-Fredrik} }